Diyala Journal For Pure Science
Scientific Refereed Journal Published By College of Science - University of Diyala
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Diyala Journal For Pure Sciences DJPS
ISRA Impact Factor:3.715
P- ISSN:2222-8373, E-ISSN:2518-9255
Volume 13, Issue 3, Part 1 , July. 2017
Synthesis and Biological Active of Some Substituted 1,2,4-Triazoles and Their Fused Ring Derivatives
Khalid Mahmod Daoud, Mohanad Yakdhan Saleh , Shaima Samer Ismael
Year: 2017, Volume: 13, Issue: 3, Part: 1
Pages: 72-87, DOI: http://dx.doi.org/10.24237/djps.1303.201C
In this paper demonstrated the synthesis of some fused 1,2,4-triazoles derivatives ; Terphthalic acid condensated with ethanol to obtain diethyl terephthalate (1) in the presence of sulfuric acid as catalyst., the ethyl ester (1) was mixed with hydrazine hydrate is ethyl alcohol to give terephthalohydrazide (2). The hydrazide derivative (2) then reacted with ammonium thiocyanate to give yield 2,2'-terephthaloylbis(hydrazinecarbothioamide) (3). 3,4- diamine-bis – 1,2,4-triazole derivative (4) was obtained by reaction of a compound (3) with hydrazine hydrate. 5,5'-(1,4-phenylene)bis(4H-1,2,4-triazole-3,4-diamine) (4) was reacted with a proper aldehyde to yield Schiff bases derivatives (5,6,7).1-(1H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-5-yl)-4-(3H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl) benzene derivatives (8,9,10) were yielded by reaction a Schiff bases derivative with glacial acetic acid. The structures of the synthesized compounds were confirmed by physical and spectral methods.
Keywords: Heterocyclic compounds, 1, 2, 4-trazole, fused ring, terephthalic acid.