Diyala Journal For Pure Science
Scientific Refereed Journal Published By College of Science - University of Diyala
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Diyala Journal For Pure Sciences DJPS
ISRA Impact Factor:3.715
P- ISSN:2222-8373, E-ISSN:2518-9255
Volume 13, Issue 3, Part 1 , July. 2017
Synthesis and Antibacterial Evaluation of 2-(chloro / ethyl thio / seleno)-1,8-naphthyridine-3-azetidine Derivatives
Year: 2017, Volume: 13, Issue: 3, Part: 1
Pages: 104-115, DOI: http://dx.doi.org/10.24237/djps.1303.217A
Synthesis of new heterocyclic fuse compounds by reaction of N-acetyl-2-amino pyridine with through Vilsmeier-Haack cyclization to give 2-chloro-3-formyl-1,8-naphthyridine (1) , chloro atom changing with selenium (2) or Et-S- group (3) , the formyl group in the compounds (1,2,3) converted to schiff base by react with aryl amine (4-9), shiff base derivatives reaction with chloroacetylchloride in triethylamine to give azetidine ring (10-15) . The structures of synthesized compounds were confirmed by spectral and physical data. Some of the newly synthesized compounds exhibited antibacterial activity.
Keywords: schiff base , 1,8-naphthyridine , azetidine , organoselenium compounds , Vilsmeier-Haack.