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Diyala Journal For Pure Science

Scientific Refereed Journal Published By College of Science - University of Diyala


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Diyala Journal For Pure Sciences DJPS

ISRA Impact Factor:3.715

P- ISSN:2222-8373, E-ISSN:2518-9255

Volume 13, Issue 1, Part 1 , January. 2017



Synthesis of some heterocyclic compounds derived from 1-Aryl-3-(4-hydroxy-3-methoxyphenyl) propene-1-one


Eman Ibrahim AL-Salihi  , Ahmad Khidr Ahmad


Year: 2017, Volume: 13, Issue: 1, Part:1


Pages: 58-73, DOI: http://dx.doi.org/10.24237/djps.1301.32B


Language: English


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A series of heterocyclic compounds have been synthesized using 1–aryl-3-(4-hydroxy-3-methoxypheny) prop-2-ene-1-one (1-4) as starting material which was prepared by claisen-schmidt condensation between vanillin and substituted acetophenone.Benzoxazepine derivatives (5-8) and benzodiazepine derivatives (9-12) were synthesized from the reaction of o-aminophenol, o-phenlendiamine with compounds (1-4) respectively. Thereaction of compounds (1-4) with hydrazine hydrate afforded pyrazol derivatives (13-16). While the reaction of compounds (1-4) with hydrazine hydrates in the presences a few drops of glacial acetic acid gave 1- acetyl pyazol derivatives (17-20). Oxirane derivatives (21-24) were synthesized from the reaction of compounds (1-4) with hydrogen peroxide in the basic medium. Reaction of phenylthiourea with compounds (1-4) afforded pyrimidinethion derivative (25-27).Finally isoxazol derivatives (28-31) were synthesized by the reaction of compounds (1-4) with hydroxylamine hydrochloride in presences of triethylamine.


Key words: vanillin;Pyrazol;Oxirane;Pyrimidinethion;Isoxazol

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