Diyala Journal For Pure Science
Scientific Refereed Journal Published By College of Science - University of Diyala
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Diyala Journal For Pure Sciences DJPS
ISRA Impact Factor:3.715
P- ISSN:2222-8373, E-ISSN:2518-9255
Volume 13, Issue 4, Part 1 , October. 2017
Preparation of Starch Grafted Methyl Nadic Anhydride and Substituted with Amino Drug
Firyal Mohammed Ali , Mohammed Alwan Farhan
Year: 2017, Volume: 13, Issue: 4, Part:1
Pages: 242-255 , DOI: http://dx.doi.org/10.24237/djps.1304.346B
The aim of this work is to improve pharmaceutical and therapeutic drugs to enable delivery to the right place, this format of carries for controlled delivery of therapeutic agent which could Release a small amount of drug over a long period of time, by graft copolymerization of methyl nadic anhydride (MNA) onto starch (M1) ,due to its biodegradable, not harmful, and slow digesting nature . It was carried out by using ceric ammonium nitrate (CAN) as an initiator, the graft copolymer was substituted with trimethoprim (M1C) as amino drug, the new prepared drug copolymer was characterized by FTIR, 1H-NMR and UV Spectroscopes. The physical properties were measured. The drug copolymers were prepared, analyzed in various pH values at (37 0C) as in vitro study and the release of controlled drugs was compared through many days analysis.
Keywords:- Starch, methyl nadic anhydride, Trimethoprim, Copolymer, Drug Copolymer.