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DJPS

Diyala Journal For Pure Science

Scientific Refereed Journal Published By College of Science - University of Diyala

 

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djps.15.01.451B

Diyala Journal For Pure Sciences DJPS

ISRA Impact Factor:3.715

P- ISSN:2222-8373, E-ISSN:2518-9255

Volume 15, Issue 1 , January . 2019

 

 

 

Synthesis, Characterization and Spectroscopic Study of Some Heterocyclic  Compounds (2,3-Dihydroquinazolin, Dzetidin-2-one) Derived from Schiff Bases and Evaluation Their Bacterial Activity

 

Khamaael. M. Fayyadh , Inam. H. Khudhair

 

Year: 2019, Volume: 15, Issue: 1

 

Pages: 38-58 , DOI: http://dx.doi.org/10.24237/djps.1501.451B

 

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Abstract


 

This search includes preparation of Schiff Bases (R1 - R4) from the reaction 2, 4- diamino-5-(3, 4, 5-trimethoxy benzyl) pyrimidine with some of aromatic aldehydes. Then preparation the compounds of tetracyclic ring as derivatives of 1, 1- (3, 4, 5-trimethoxybenzyl) pyrimidine-2, 4 diyl) bis (3-chloro-4-(substituted phenyl) azetidin-2-one) (R5-R8), from reaction of Schiff bases (R1-R4) with chloro acetyl chloride in presence of tri ethyl amine in 1, 4-dioxane. And also, preparation of hexacyclic as derivatives 3, 3-(3, 4, 5-trimethoxybenzyl) pyrimidine-2,4diyl)-bis(2(substitutedphenyl)-2,3-dihydroquinazolin-4 (1H) one) (R9-R12) with 2-amino-benzoic acid by using 1, 4- dioxane as a solvent. The structure of the synthesized compounds was confirmed by (I.R) and (1H-NMR) spectrum, as well as, the physical means such color and melting point, the biological activity was studied against of some kind of bacteria.

 

Keywords: 2, 4-diamino-5-(3, 4, 5-trimethoxy benzyl) pyrimidine, azetidin-2-one, dihydroquinazolin-4, Schiff base

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